Review

metacore tm software (GeneGo Inc)

About

News

Press Release

Team

Advisors

Partners

Contact

Bioz Stars

Bioz vStars

Buy from Supplier

Structured Review

GeneGo Inc metacore tm software

<t>MetaCore</t> TM analysis of protein interactions. Protein–protein interaction network for DEPs in TR MCF-7 cells obtained from adiponectin-treated secondary-generation mammospheres compared to untreated cells (control, C). ( A ) MetaCore TM analysis of the network showing the Adiponectin Receptor 1 (AdipoR1)-Notch-Cyclin D1 ( p -value > 1.733 × 10 −8 ) interaction. Blue circles indicate downregulated proteins, while red circles mark upregulated proteins. ( B ) Enrichment analysis using the most significant GO annotations according to biological processes. The bar graph displays the significant biological processes of the hub proteins present in the network.

Metacore Tm Software, supplied by GeneGo Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/metacore+tm+software/metacore+software/pmc11853953-125-7-9
Average 90 stars, based on 1 article reviews

metacore tm software - by Bioz Stars, 2026-09

90/100 stars

Images

1) Product Images from "Adiponectin Influences the Behavior of Stem Cells in Hormone-Resistant Breast Cancer"

Article Title: Adiponectin Influences the Behavior of Stem Cells in Hormone-Resistant Breast Cancer

Journal: Cells

doi: 10.3390/cells14040286

MetaCore TM analysis of protein interactions. Protein–protein interaction network for DEPs in TR MCF-7 cells obtained from adiponectin-treated secondary-generation mammospheres compared to untreated cells (control, C). ( A ) MetaCore TM analysis of the network showing the Adiponectin Receptor 1 (AdipoR1)-Notch-Cyclin D1 ( p -value > 1.733 × 10 −8 ) interaction. Blue circles indicate downregulated proteins, while red circles mark upregulated proteins. ( B ) Enrichment analysis using the most significant GO annotations according to biological processes. The bar graph displays the significant biological processes of the hub proteins present in the network.

Figure Legend Snippet: MetaCore TM analysis of protein interactions. Protein–protein interaction network for DEPs in TR MCF-7 cells obtained from adiponectin-treated secondary-generation mammospheres compared to untreated cells (control, C). ( A ) MetaCore TM analysis of the network showing the Adiponectin Receptor 1 (AdipoR1)-Notch-Cyclin D1 ( p -value > 1.733 × 10 −8 ) interaction. Blue circles indicate downregulated proteins, while red circles mark upregulated proteins. ( B ) Enrichment analysis using the most significant GO annotations according to biological processes. The bar graph displays the significant biological processes of the hub proteins present in the network.

Techniques Used: Control

MetaCore TM interaction network analysis. Protein–protein interaction network for DEPs in TR MCF-7 cells obtained from adiponectin-treated secondary-generation mammospheres compared to untreated cells (control, C). ( A ) MetaCore TM analysis of the network evidencing the BID-Notch-AdipoR1 interaction ( p -value > 1.80 × 10 −8 ). Blue circles indicate downregulated proteins, while red circles mark upregulated proteins. ( B ) Enrichment analysis using the most significant GO annotations according to biological processes. The bar graph shows the significant biological processes of the hub proteins present in the network.

Figure Legend Snippet: MetaCore TM interaction network analysis. Protein–protein interaction network for DEPs in TR MCF-7 cells obtained from adiponectin-treated secondary-generation mammospheres compared to untreated cells (control, C). ( A ) MetaCore TM analysis of the network evidencing the BID-Notch-AdipoR1 interaction ( p -value > 1.80 × 10 −8 ). Blue circles indicate downregulated proteins, while red circles mark upregulated proteins. ( B ) Enrichment analysis using the most significant GO annotations according to biological processes. The bar graph shows the significant biological processes of the hub proteins present in the network.

Techniques Used: Control

Software:

Article Title: Genome Analysis Reveals a Synergistic Mechanism of Ursodeoxycholic Acid and Jasminoidin in Mice Brain Repair After Ischemia/Reperfusion: Crosstalk Among Muti-Pathways
Article Snippet: .. This study aimed to further investigate the mechanisms by which UA and JA combination protects against brain ischemia with GeneGo MetaCore TM software. .. GeneGo MetaCore TM is a pathway analysis tool based on a proprietary manually curated database of various high throughput data ( ).

Article Title: Adiponectin Influences the Behavior of Stem Cells in Hormone-Resistant Breast Cancer
Article Snippet: The mass spectrometry proteomics data have been deposited to the ProteomeXchange Consortium via the PRIDE partner repository with the dataset identifier PXD059964. .. For network and enrichment analysis, we used MetaCore TM (GeneGo, Clarivate Analytics, London, UK) software, a knowledge database suitable for pathway analysis of experimental data and gene lists. ..

Article Title: Effect of Hyperglycemia on Gene Expression during Early Organogenesis in Mice
Article Snippet: .. Pathway analysis with MetaCore TM software (GeneGo, Inc., St. Joseph, MI, USA) was used to assess the significance of changes in gene expression in specified pathways [ , ]. ..

Article Title: Causes and Clinical Features of Infertile Men With Nonobstructive Azoospermia and Histopathologic Diagnosis of Hypospermatogenesis.
Article Snippet: 1 Manuscript text: 2993 Page 1 of 22 2

Article Title: Sixteen-Year Longitudinal Evaluation of Blood-Based DNA Methylation Biomarkers for Early Prediction of Alzheimer’s Disease
Article Snippet: .. Enrichment by ‘disease biomarker networks’, and ‘diseases (by biomarkers)’ was performed with GeneGo MetaCore TM software ( https://portal.genego.com/ ). ..

Article Title: Alcohol consumption modulates host defense in rhesus macaques by altering gene expression in circulating leukocytes
Article Snippet: .. Enrichment analysis of functional annotations was performed to identify significant biological pathways including gene ontology (GO) terms and disease biomarkers using MetaCore TM software (GeneGo, Philadelphia, PA). ..

Article Title: Genome Analysis Reveals a Synergistic Mechanism of Ursodeoxycholic Acid and Jasminoidin in Mice Brain Repair After Ischemia/Reperfusion: Crosstalk Among Muti-Pathways
Article Snippet: .. This time the biological verification of JUNB by Western Blotting indicated that the level of down-regulation in UA group was greater than that of JA and JU groups, in line with the findings of microarray data analysis and GeneGo MetaCore TM software. ..

Gene Expression:

Article Title: Anthocyanins and their gut metabolites attenuate monocyte adhesion and transendothelial migration through nutrigenomic mechanisms regulating endothelial cell permeability.
Article Snippet: Cardioprotective effects of dietary anthocyanins are partly attributed to their ability to maintain endothelial function.. However, the underlying cellular and molecular mechanisms of action are not fully understood.. This study aimed to evaluate the effect of anthocyanins and their gut metabolites, at physiologically-relevant conditions, on endothelial cell (EC) function and decipher the underlying molecular mechanisms of action using integrated omics approaches.

Biomarker Discovery:

Functional Assay:

Western Blot:

Article Title: Genome Analysis Reveals a Synergistic Mechanism of Ursodeoxycholic Acid and Jasminoidin in Mice Brain Repair After Ischemia/Reperfusion: Crosstalk Among Muti-Pathways
Article Snippet: .. This time the biological verification of JUNB by Western Blotting indicated that the level of down-regulation in UA group was greater than that of JA and JU groups, in line with the findings of microarray data analysis and GeneGo MetaCore TM software. ..

Microarray:

Article Title: Genome Analysis Reveals a Synergistic Mechanism of Ursodeoxycholic Acid and Jasminoidin in Mice Brain Repair After Ischemia/Reperfusion: Crosstalk Among Muti-Pathways
Article Snippet: .. This time the biological verification of JUNB by Western Blotting indicated that the level of down-regulation in UA group was greater than that of JA and JU groups, in line with the findings of microarray data analysis and GeneGo MetaCore TM software. ..

Image Search Results

Journal: Cells

Article Title: Adiponectin Influences the Behavior of Stem Cells in Hormone-Resistant Breast Cancer

doi: 10.3390/cells14040286

Figure Lengend Snippet: MetaCore TM analysis of protein interactions. Protein–protein interaction network for DEPs in TR MCF-7 cells obtained from adiponectin-treated secondary-generation mammospheres compared to untreated cells (control, C). ( A ) MetaCore TM analysis of the network showing the Adiponectin Receptor 1 (AdipoR1)-Notch-Cyclin D1 ( p -value > 1.733 × 10 −8 ) interaction. Blue circles indicate downregulated proteins, while red circles mark upregulated proteins. ( B ) Enrichment analysis using the most significant GO annotations according to biological processes. The bar graph displays the significant biological processes of the hub proteins present in the network.

Article Snippet: For network and enrichment analysis, we used MetaCore TM (GeneGo, Clarivate Analytics, London, UK) software, a knowledge database suitable for pathway analysis of experimental data and gene lists.

Techniques: Control

Journal: Cells

Article Title: Adiponectin Influences the Behavior of Stem Cells in Hormone-Resistant Breast Cancer

doi: 10.3390/cells14040286

Figure Lengend Snippet: MetaCore TM interaction network analysis. Protein–protein interaction network for DEPs in TR MCF-7 cells obtained from adiponectin-treated secondary-generation mammospheres compared to untreated cells (control, C). ( A ) MetaCore TM analysis of the network evidencing the BID-Notch-AdipoR1 interaction ( p -value > 1.80 × 10 −8 ). Blue circles indicate downregulated proteins, while red circles mark upregulated proteins. ( B ) Enrichment analysis using the most significant GO annotations according to biological processes. The bar graph shows the significant biological processes of the hub proteins present in the network.

Techniques: Control

Shared significantly altered gene sets between PD, HGPS, AD and PM, determined using GeneGO MetaCore TM enrichment analysis (adjusted p -value ≤0.05): a ) shared canonical pathways; b ) shared GO biological processes. *: significant overlap by Fisher’s exact test ( p -value ≤0.05)

Journal: BMC Medical Genomics

Article Title: Comparative transcriptome analysis of Parkinson’s disease and Hutchinson-Gilford progeria syndrome reveals shared susceptible cellular network processes

doi: 10.1186/s12920-020-00761-6

Figure Lengend Snippet: Shared significantly altered gene sets between PD, HGPS, AD and PM, determined using GeneGO MetaCore TM enrichment analysis (adjusted p -value ≤0.05): a ) shared canonical pathways; b ) shared GO biological processes. *: significant overlap by Fisher’s exact test ( p -value ≤0.05)

Article Snippet: Alterations in the activity of pathways and biological processes were investigated using the software tool GeneGO MetaCore TM ( https://portal.genego.com/ ).

Techniques:

a Overlap of significantly altered subnetworks between PD, HGPS, AD and PM, determined using GeneGO MetaCore TM network analysis. b Shared GO biological processes among the subnetworks for PD, HGPS, AD and PM. *: significant overlap by Fisher’s exact test ( p -value ≤0.05)

Journal: BMC Medical Genomics

Article Title: Comparative transcriptome analysis of Parkinson’s disease and Hutchinson-Gilford progeria syndrome reveals shared susceptible cellular network processes

doi: 10.1186/s12920-020-00761-6

Figure Lengend Snippet: a Overlap of significantly altered subnetworks between PD, HGPS, AD and PM, determined using GeneGO MetaCore TM network analysis. b Shared GO biological processes among the subnetworks for PD, HGPS, AD and PM. *: significant overlap by Fisher’s exact test ( p -value ≤0.05)

Article Snippet: Alterations in the activity of pathways and biological processes were investigated using the software tool GeneGO MetaCore TM ( https://portal.genego.com/ ).

Techniques:

ERK5 regulates the polymerization of F-actin . (A) Ontological categories of differentially expressed proteins in ERK5-overexpression A549 cells by Metacore TM GeneGo Pathway Maps analysis. (B) Protein networks associated with the actin regulators differentially expressed in ERK5-overexpression A549 cells (higher definition image is shown in Supplementary file 2: Fig. S4). The network was generated by a shortest paths algorithm of MetaCore TM (GeneGo) software using the list of differentially expressed actin regulators identified by proteomics analysis. (C) Western blot analysis of actin nucleation and polymerization correlated proteins in ERK5-overexpression A549 cells, including ERK5, Gelsolin, N-WASP, p-PLK1and SPA1. (D) The cell shapes of A549 cells overexpressing ERK5 under light microscope. (E) ERK5 regulated the assembly of F-actin. Immunofluorescence was carried out to display F-actin (phalloidin, red), and nuclei (Hochest, blue) in ERK5-overexpression A549 cells and control A549 cells. (F) After serum starvation overnight, the cells were stimulated again with 20% fetal calf serum for 2 h. Then immunofluorescence assay was performed as that described in (E)

Journal: Protein & Cell

Article Title: Extracellular signal regulated kinase 5 promotes cell migration, invasion and lung metastasis in a FAK-dependent manner

doi: 10.1007/s13238-020-00701-1

Figure Lengend Snippet: ERK5 regulates the polymerization of F-actin . (A) Ontological categories of differentially expressed proteins in ERK5-overexpression A549 cells by Metacore TM GeneGo Pathway Maps analysis. (B) Protein networks associated with the actin regulators differentially expressed in ERK5-overexpression A549 cells (higher definition image is shown in Supplementary file 2: Fig. S4). The network was generated by a shortest paths algorithm of MetaCore TM (GeneGo) software using the list of differentially expressed actin regulators identified by proteomics analysis. (C) Western blot analysis of actin nucleation and polymerization correlated proteins in ERK5-overexpression A549 cells, including ERK5, Gelsolin, N-WASP, p-PLK1and SPA1. (D) The cell shapes of A549 cells overexpressing ERK5 under light microscope. (E) ERK5 regulated the assembly of F-actin. Immunofluorescence was carried out to display F-actin (phalloidin, red), and nuclei (Hochest, blue) in ERK5-overexpression A549 cells and control A549 cells. (F) After serum starvation overnight, the cells were stimulated again with 20% fetal calf serum for 2 h. Then immunofluorescence assay was performed as that described in (E)

Article Snippet: The network was generated by a shortest paths algorithm of MetaCore TM (GeneGo) software using the list of differentially expressed actin regulators identified by proteomics analysis. (C) Western blot analysis of actin nucleation and polymerization correlated proteins in ERK5-overexpression A549 cells, including ERK5, Gelsolin, N-WASP, p-PLK1and SPA1. (D) The cell shapes of A549 cells overexpressing ERK5 under light microscope. (E) ERK5 regulated the assembly of F-actin.

Techniques: Over Expression, Generated, Software, Western Blot, Light Microscopy, Immunofluorescence, Control

Review

metacore tm software (GeneGo Inc)

Structured Review

Images

1) Product Images from "Adiponectin Influences the Behavior of Stem Cells in Hormone-Resistant Breast Cancer"

Related Articles

Software:

Gene Expression:

Biomarker Discovery:

Functional Assay:

Western Blot:

Microarray:

Similar Products

Image Search Results